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Analyzing the Gut Microbiome

The Huttenhower Lab at the Harvard Chan Center for the Microbiome in Public Health focuses on understanding the function of microbial communities, particularly in humans. This involves using the microbiome to predict disease onset, progression, and outcomes, as well as developing methods to modify it for health and treatment, applicable to conditions like IBD, cancer, diabetes, arthritis, and infections.

A recent paper from the lab explores how changes in the gut microbiome are linked to different types of inflammatory arthritis, aiming to identify specific bacteria and metabolic pathways that might contribute to these diseases. 

Computers are needed to analyze the large amounts of data from the gut microbiome, as the researchers seek to identify patterns and connections between specific bacteria and different types of inflammatory arthritis, including using software to process and interpret the complex biological information.

The study found that certain types of bacteria in the gut are linked to different forms of inflammatory arthritis, suggesting that the gut microbiome plays a key role in these diseases. The researchers also identified specific metabolic pathways that might be involved, offering potential new targets for treatment.

The Huttenhower Lab
Department of Biostatistics, Harvard T.H. Chan School of Public Health

Research projects

Denser Environments Cultivate Larger Galaxies
Modeling Hydrogels and Elastomers
Exact Gravitational Lensing by Rotating Black Holes
Yale Budget Lab
Simulating Large Biomolecular Assemblies
Evolution of Viral Infectious Disease
QuEra at the MGHPCC
NeuraChip
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